Publication: Peripheral mitochondrial dysfunction in Alzheimer's disease: focus on lymphocytes
Peripheral mitochondrial dysfunction in Alzheimer's disease: focus on lymphocytes
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Leuner, K., Schulz, K., Schütt, T., Pantel, J., Prvulovic, D., Rhein, V., Savaskan, E., Czech, C., Eckert, A., & Müller, W. E. (2012). Peripheral mitochondrial dysfunction in Alzheimer’s disease: focus on lymphocytes. Molecular Neurobiology, 46(1), 194–204. https://doi.org/10.1007/s12035-012-8300-y
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Alzheimer's disease (AD) is the most common progressive neurodegenerative disease. Today, AD affects millions of people worldwide and the number of AD cases will increase with increased life expectancy. The AD brain is marked by severe neurodegeneration like the loss of synapses and neurons, atrophy and depletion of neurotransmitter systems in the hippocampus and cerebral cortex. Recent findings suggest that these pathological changes are causally induced by mitochondrial dysfunction and increased oxidative stress. These changes are n
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- Leuner, Kristina
- Schulz, Kathrin
- Schütt, Tanja
- Pantel, Johannes
- Prvulovic, David
- Rhein, Virginie
- Savaskan, Egemen
- Czech, Christian
- Eckert, Anne
- Müller, Walter E
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Leuner, K., Schulz, K., Schütt, T., Pantel, J., Prvulovic, D., Rhein, V., Savaskan, E., Czech, C., Eckert, A., & Müller, W. E. (2012). Peripheral mitochondrial dysfunction in Alzheimer’s disease: focus on lymphocytes. Molecular Neurobiology, 46(1), 194–204. https://doi.org/10.1007/s12035-012-8300-y