Comparison of two different coagulation algorithms on the use of allogenic blood products and coagulation factors in severely injured trauma patients: a retrospective, multicentre, observational study

Kaserer, Alexander; Casutt, Mattias; Sprengel, Kai; Seifert, Burkhardt; Spahn, Donat R; Stein, Philipp

doi:10.1186/s13049-017-0463-0

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Kaserer, A., Casutt, M., Sprengel, K., Seifert, B., Spahn, D. R., & Stein, P. (2018). Comparison of two different coagulation algorithms on the use of allogenic blood products and coagulation factors in severely injured trauma patients: a retrospective, multicentre, observational study. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 26:4. https://doi.org/10.1186/s13049-017-0463-0

Abstract

BACKGROUND:At the University Hospital Zurich (USZ) and the Cantonal Hospital of Lucerne (LUKS) an individualized goal-directed coagulation and transfusion algorithm was introduced and implemented before 2012 (Coagulation algorithm of the USZ: USZ-Alg; of the LUKS: LUKS-Alg). Main differences between both algorithms are: 1) A target haematocrit-range of 0.21-0.24 (USZ-Alg) vs. a lower haematocrit limit only (LUKS-Alg). 2) Blind coagulation-package in selected cases (LUKS-Alg only). 3) Factor XIII substitution is considered earlier acco