Contact Heat Evoked Potentials Are Responsive to Peripheral Sensitization: Requisite Stimulation Parameters

Linde, Lukas D; Haefeli, Jenny; Jutzeler, Catherine R; Rosner, Jan; McDougall, Jessica; Curt, Armin; Kramer, John L K

doi:10.3389/fnhum.2019.00459

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Linde, L. D., Haefeli, J., Jutzeler, C. R., Rosner, J., McDougall, J., Curt, A., & Kramer, J. L. K. (2019). Contact Heat Evoked Potentials Are Responsive to Peripheral Sensitization: Requisite Stimulation Parameters. Frontiers in Human Neuroscience, 13, 459. https://doi.org/10.3389/fnhum.2019.00459

Abstract

The sensitizing effect of capsaicin has been previously characterized using laser and contact heat evoked potentials (LEPs and CHEPs) by stimulating in the primary area of hyperalgesia. Interestingly, only CHEPs reveal changes consistent with notion of peripheral sensitization (i.e., reduced latencies). The aim of this study was to investigate contact heat stimulation parameters necessary to detect peripheral sensitization related to the topical application of capsaicin, and therefore significantly improve the current method of measur