Publication: Integrating force-sensing and signaling pathways in a model for the regulation of wing imaginal disc size
Integrating force-sensing and signaling pathways in a model for the regulation of wing imaginal disc size
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Aegerter-Wilmsen, T., Heimlicher, M. B., Smith, A. C., de Reuille, P. B., Smith, R. S., Aegerter, C. M., & Basler, K. (2012). Integrating force-sensing and signaling pathways in a model for the regulation of wing imaginal disc size. Development, 139, 3221–3231. https://doi.org/10.1242/dev.082800
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The regulation of organ size constitutes a major unsolved question in developmental biology. The wing imaginal disc of Drosophila serves as a widely used model system to study this question. Several mechanisms have been proposed to have an impact on final size, but they are either contradicted by experimental data or they cannot explain a number of key experimental observations and may thus be missing crucial elements. We have modeled a regulatory network that integrates the experimentally confirmed molecular interactions underlying o
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- Aegerter-Wilmsen, Tinri
- Heimlicher, Maria B
- Smith, Alister C
- de Reuille, Pierre Barbier
- Smith, Richard S
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Aegerter-Wilmsen, T., Heimlicher, M. B., Smith, A. C., de Reuille, P. B., Smith, R. S., Aegerter, C. M., & Basler, K. (2012). Integrating force-sensing and signaling pathways in a model for the regulation of wing imaginal disc size. Development, 139, 3221–3231. https://doi.org/10.1242/dev.082800
