Publication: The Influence of the Cytoskeleton on the Development and Behavior of Viral Factories in Mammalian Orthoreovirus
The Influence of the Cytoskeleton on the Development and Behavior of Viral Factories in Mammalian Orthoreovirus
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Lee, M., Vetter, J., & Eichwald, C. (2025). The Influence of the Cytoskeleton on the Development and Behavior of Viral Factories in Mammalian Orthoreovirus. Virology, 604, 110423. https://doi.org/10.1016/j.virol.2025.110423
Abstract
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Abstract
Cytosolic viral factories (VFs) of mammalian orthoreovirus (MRV) are sites for viral genome replication and assembly of virus progeny. Despite advancements in reverse genetics, the formation and dynamics of VFs still need to be clarified. MRV exploits host cytoskeletal components like microtubules (MTs) throughout its life cycle, including cell entry, replication, and release. MRV VFs, membrane-less cytosolic inclusions, rely on the viral proteins μ2 and μNS for formation. Protein μ2 interacts and stabilizes MTs through acetylation, s
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- Lee, Melissa
- Vetter, Janine
- Eichwald, Catherine
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Lee, M., Vetter, J., & Eichwald, C. (2025). The Influence of the Cytoskeleton on the Development and Behavior of Viral Factories in Mammalian Orthoreovirus. Virology, 604, 110423. https://doi.org/10.1016/j.virol.2025.110423
