Publication: Rac regulates giardia lamblia encystation by coordinating cyst wall protein trafficking and secretion
Rac regulates giardia lamblia encystation by coordinating cyst wall protein trafficking and secretion
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Krtková, J., Thomas, E. B., Alas, G. C. M., Schraner, E. M., Behjatnia, H. R., Hehl, A. B., & Paredez, A. R. (2016). Rac regulates giardia lamblia encystation by coordinating cyst wall protein trafficking and secretion. MBio, 7(4), e01003–e01016. https://doi.org/10.1128/mBio.01003-16
Abstract
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Abstract
UNLABELLED Encystation of the common intestinal parasite Giardia lamblia involves the production, trafficking, and secretion of cyst wall material (CWM). However, the molecular mechanism responsible for the regulation of these sequential processes remains elusive. Here, we examined the role of GlRac, Giardia's sole Rho family GTPase, in the regulation of endomembrane organization and cyst wall protein (CWP) trafficking. Localization studies indicated that GlRac is associated with the endoplasmic reticulum (ER) and the Golgi apparatus-
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- Krtková, Jana
- Thomas, Elizabeth B
- Alas, Germain C M
- Schraner, Elisabeth M
- Behjatnia, Habib R
- Hehl, Adrian B
- Paredez, Alexander R
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Krtková, J., Thomas, E. B., Alas, G. C. M., Schraner, E. M., Behjatnia, H. R., Hehl, A. B., & Paredez, A. R. (2016). Rac regulates giardia lamblia encystation by coordinating cyst wall protein trafficking and secretion. MBio, 7(4), e01003–e01016. https://doi.org/10.1128/mBio.01003-16
