Publication: Enzyme responsive GAG-based natural-synthetic hybrid hydrogel for tunable growth factor delivery and stem cell differentiation
Enzyme responsive GAG-based natural-synthetic hybrid hydrogel for tunable growth factor delivery and stem cell differentiation
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Anjum, F., Lienemann, P. S., Metzger, S., Biernaskie, J., Kallos, M. S., & Ehrbar, M. (2016). Enzyme responsive GAG-based natural-synthetic hybrid hydrogel for tunable growth factor delivery and stem cell differentiation. Biomaterials, 87, 104–117. https://doi.org/10.1016/j.biomaterials.2016.01.050
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We describe an enzymatically formed chondroitin sulfate (CS) and poly(ethylene glycol) (PEG) based hybrid hydrogel system, which by tuning the architecture and composition of modular building blocks, allows the application-specific tailoring of growth factor delivery and cellular responses. CS, a negatively charged sulfate-rich glycosaminoglycan of the extracellular matrix (ECM), known for its growth factor binding and stem cell regulatory functions, is used as a starting material for the engineering of this biomimetic materials platf
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- Anjum, Fraz
- Lienemann, Philipp S
- Metzger, Stéphanie
- Biernaskie, Jeff
- Kallos, Michael S
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Anjum, F., Lienemann, P. S., Metzger, S., Biernaskie, J., Kallos, M. S., & Ehrbar, M. (2016). Enzyme responsive GAG-based natural-synthetic hybrid hydrogel for tunable growth factor delivery and stem cell differentiation. Biomaterials, 87, 104–117. https://doi.org/10.1016/j.biomaterials.2016.01.050
