Publication: Novel regulators of PrPC biosynthesis revealed by genome-wide RNA interference
Novel regulators of PrPC biosynthesis revealed by genome-wide RNA interference
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Heinzer, D., Avar, M., Pease, D. P., Dhingra, A., Yin, J.-A., Schaper, E., Doğançay, B., Emmenegger, M., Spinelli, A., Maggi, K., Chincisan, A., Mead, S., Hornemann, S., Heutink, P., & Aguzzi, A. (2021). Novel regulators of PrPC biosynthesis revealed by genome-wide RNA interference. PLoS Pathogens, 17(10), e1010013. https://doi.org/10.1371/journal.ppat.1010013
Abstract
Abstract
Abstract
The cellular prion protein PrPC is necessary for prion replication, and its reduction greatly increases life expectancy in animal models of prion infection. Hence the factors controlling the levels of PrPC may represent therapeutic targets against human prion diseases. Here we performed an arrayed whole-transcriptome RNA interference screen to identify modulators of PrPC expression. We cultured human U251-MG glioblastoma cells in the presence of 64'752 unique siRNAs targeting 21'584 annotated human genes, and measured PrPC using a one
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Creators (Authors)
- Avar, Merve
- Pease, Daniel Patrick
- Dhingra, Ashutosh
- Schaper, Elke
- Doğançay, Berre
- Emmenegger, Marc
- Spinelli, Anna
- Maggi, Kevin
- Chincisan, Andra
- Mead, Simon
- Heutink, Peter
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Citations
Heinzer, D., Avar, M., Pease, D. P., Dhingra, A., Yin, J.-A., Schaper, E., Doğançay, B., Emmenegger, M., Spinelli, A., Maggi, K., Chincisan, A., Mead, S., Hornemann, S., Heutink, P., & Aguzzi, A. (2021). Novel regulators of PrPC biosynthesis revealed by genome-wide RNA interference. PLoS Pathogens, 17(10), e1010013. https://doi.org/10.1371/journal.ppat.1010013
