Publication: Receptor-gated IL-2 delivery by an anti-human IL-2 antibody activates regulatory T cells in three different species
Receptor-gated IL-2 delivery by an anti-human IL-2 antibody activates regulatory T cells in three different species
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Karakus, U., Sahin, D., Mittl, P. R. E., Mooij, P., Koopman, G., & Boyman, O. (2020). Receptor-gated IL-2 delivery by an anti-human IL-2 antibody activates regulatory T cells in three different species. Science Translational Medicine, 12, eabb9283. https://doi.org/10.1126/scitranslmed.abb9283
Abstract
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Abstract
Stimulation of regulatory T (Treg) cells holds great promise for the treatment of autoimmune, chronic inflammatory, and certain metabolic diseases. Recent clinical trials with low-dose interleukin-2 (IL-2) to expand Treg cells led to beneficial results in autoimmunity, but IL-2 immunotherapy can activate both Treg cells and pathogenic T cells. Use of IL-2 receptor α (IL-2Rα, CD25)-biased IL-2/anti-IL-2 antibody complexes improves IL-2 selectivity for Treg cells; however, the mechanism of action of such IL-2 complexes is incompletely u
Additional indexing
Creators (Authors)
- Karakus, Ufuk
- Sahin, Dilara
- Mittl, Peer R E
- Mooij, Petra
- Koopman, Gerrit
- Boyman, Onur
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Citations
Karakus, U., Sahin, D., Mittl, P. R. E., Mooij, P., Koopman, G., & Boyman, O. (2020). Receptor-gated IL-2 delivery by an anti-human IL-2 antibody activates regulatory T cells in three different species. Science Translational Medicine, 12, eabb9283. https://doi.org/10.1126/scitranslmed.abb9283
