Publication: Patterned Vascularization of Embryonic Mouse Forebrain, and Neuromeric Topology of Major Human Subarachnoidal Arterial Branches: A Prosomeric Mapping
Patterned Vascularization of Embryonic Mouse Forebrain, and Neuromeric Topology of Major Human Subarachnoidal Arterial Branches: A Prosomeric Mapping
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Puelles, L., Martínez-Marin, R., Melgarejo-Otalora, P., Ayad, A., Valavanis, A., & Ferran, J. L. (2019). Patterned Vascularization of Embryonic Mouse Forebrain, and Neuromeric Topology of Major Human Subarachnoidal Arterial Branches: A Prosomeric Mapping. Frontiers in Neuroanatomy, 13, 59. https://doi.org/10.3389/fnana.2019.00059
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The prosomeric brain model contemplates progressive regionalization of the central nervous system (CNS) from a molecular and morphological ontogenetic perspective. It defines the forebrain axis relative to the notochord, and contemplates intersecting longitudinal (zonal, columnar) and transversal (neuromeric) patterning mechanisms. A checkboard pattern of histogenetic units of the neural wall results, where each unit is differentially fated by an unique profile of active genes. These natural neural units later expand their radial dime
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Puelles, L., Martínez-Marin, R., Melgarejo-Otalora, P., Ayad, A., Valavanis, A., & Ferran, J. L. (2019). Patterned Vascularization of Embryonic Mouse Forebrain, and Neuromeric Topology of Major Human Subarachnoidal Arterial Branches: A Prosomeric Mapping. Frontiers in Neuroanatomy, 13, 59. https://doi.org/10.3389/fnana.2019.00059