Publication: Drug-sensing hydrogels for the inducible release of biopharmaceuticals
Drug-sensing hydrogels for the inducible release of biopharmaceuticals
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Ehrbar, M., Schoenmakers, R., Christen, E. H., Fussenegger, M., & Weber, W. (2008). Drug-sensing hydrogels for the inducible release of biopharmaceuticals. Nature Materials, 7(10), 800–804. https://doi.org/10.1038/nmat2250
Abstract
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Drug-dependent dissociation or association of cellular receptors represents a potent pharmacologic mode of action for regulating cell fate and function. Transferring the knowledge of pharmacologically triggered protein-protein interactions to materials science will enable novel design concepts for stimuli-sensing smart hydrogels. Here, we show the design and validation of an antibiotic-sensing hydrogel for the trigger-inducible release of human vascular endothelial growth factor. Genetically engineered bacterial gyrase subunit B (GyrB
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- Schoenmakers, R
- Christen, E H
- Fussenegger, M
- Weber, W
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Ehrbar, M., Schoenmakers, R., Christen, E. H., Fussenegger, M., & Weber, W. (2008). Drug-sensing hydrogels for the inducible release of biopharmaceuticals. Nature Materials, 7(10), 800–804. https://doi.org/10.1038/nmat2250
