Publication: Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cells
Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cells
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Montavon, G., Jauquier, N., Coulon, A., Peuchmaur, M., Flahaut, M., Bourloud, K. B., Yan, P., Delattre, O., Sommer, L., Joseph, J.-M., Janoueix-Lerosey, I., Gross, N., & Mühlethaler-Mottet, A. (2014). Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cells. OncoTarget, 5(12), 4452–4466. https://doi.org/10.18632/oncotarget.2036
Abstract
Abstract
Abstract
The anaplastic lymphoma kinase (ALK) gene is overexpressed, mutated or amplified in most neuroblastoma (NB), a pediatric neural crest-derived embryonal tumor. The two most frequent mutations, ALK-F1174L and ALK-R1275Q, contribute to NB tumorigenesis in mouse models, and cooperate with MYCN in the oncogenic process. However, the precise role of activating ALK mutations or ALK-wt overexpression in NB tumor initiation needs further clarification. Human ALK-wt, ALK-F1174L, or ALK-R1275Q were stably expressed in murine neural crest progeni
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Creators (Authors)
- Montavon, Gisèle
- Jauquier, Nicolas
- Coulon, Aurélie
- Peuchmaur, Michel
- Flahaut, Marjorie
- Bourloud, Katia Balmas
- Yan, Pu
- Delattre, Olivier
- Sommer, Lukas
- Joseph, Jean-Marc
- Janoueix-Lerosey, Isabelle
- Gross, Nicole
- Mühlethaler-Mottet, Annick
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Montavon, G., Jauquier, N., Coulon, A., Peuchmaur, M., Flahaut, M., Bourloud, K. B., Yan, P., Delattre, O., Sommer, L., Joseph, J.-M., Janoueix-Lerosey, I., Gross, N., & Mühlethaler-Mottet, A. (2014). Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cells. OncoTarget, 5(12), 4452–4466. https://doi.org/10.18632/oncotarget.2036
