Publication: Klf4 is a transcriptional regulator of genes critical for EMT, including Jnk1 (Mapk8).
Klf4 is a transcriptional regulator of genes critical for EMT, including Jnk1 (Mapk8).
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Tiwari, N., Meyer-Schaller, N., Arnold, P., Antoniadis, H., Pachkov, M., van Nimwegen, E., & Christofori, G. (2013). Klf4 is a transcriptional regulator of genes critical for EMT, including Jnk1 (Mapk8). PLoS ONE, 8(2), e57329. https://doi.org/10.1371/journal.pone.0057329
Abstract
Abstract
Abstract
We have identified the zinc-finger transcription factor Kruppel-like factor 4 (Klf4) among the transcription factors that are significantly downregulated in their expression during epithelial-mesenchymal transition (EMT) in mammary epithelial cells and in breast cancer cells. Loss and gain of function experiments demonstrate that the down-regulation of Klf4 expression is required for the induction of EMT in vitro and for metastasis in vivo. In addition, reduced Klf4 expression correlates with shorter disease-free survival of subsets o
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- Tiwari, Neha
- Meyer-Schaller, Nathalie
- Arnold, Phil
- Antoniadis, Helena
- Pachkov, Mikhail
- van Nimwegen, Erik
- Christofori, Gerhard
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Tiwari, N., Meyer-Schaller, N., Arnold, P., Antoniadis, H., Pachkov, M., van Nimwegen, E., & Christofori, G. (2013). Klf4 is a transcriptional regulator of genes critical for EMT, including Jnk1 (Mapk8). PLoS ONE, 8(2), e57329. https://doi.org/10.1371/journal.pone.0057329
