Publication: Sequestration of biological reactive intermediates by trapping as covalent enzyme-intermediate complex
Sequestration of biological reactive intermediates by trapping as covalent enzyme-intermediate complex
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Oesch, F., Herrero, M. E., Lohmann, M., Hengstler, J. G., & Arand, M. (2001). Sequestration of biological reactive intermediates by trapping as covalent enzyme-intermediate complex. In P. Dansette & et al (Eds.), Biological Reactive Intermediates VI : Chemical and Biological Mechanisms in Susceptibility to and Prevention of Environmental Diseases (No. 500; Vol. 500, Issue 500, pp. 577–586). Springer. https://doi.org/10.1007/978-1-4615-0667-6_86
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One important class of biological reactive intermediates arising in the course of human xenobiotic metabolism are arene and alkene oxides. The major safeguard against the potential genotoxic effects of these compounds is the microsomal epoxide hydrolase (mEH). This enzyme has a broad substrate specificity but--on the first sight--seems to be inadequately suited for this protection task due to its low turnover number with most of its substrates. The recent progress in the understanding of the mechanism of enzymatic epoxide hydrolysis h
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- Oesch, Franz
- Herrero, Maria Elena
- Lohmann, Matthias
- Hengstler, Jan Georg
- Arand, Michael
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Oesch, F., Herrero, M. E., Lohmann, M., Hengstler, J. G., & Arand, M. (2001). Sequestration of biological reactive intermediates by trapping as covalent enzyme-intermediate complex. In P. Dansette & et al (Eds.), Biological Reactive Intermediates VI : Chemical and Biological Mechanisms in Susceptibility to and Prevention of Environmental Diseases (No. 500; Vol. 500, Issue 500, pp. 577–586). Springer. https://doi.org/10.1007/978-1-4615-0667-6_86
