Publication: A stable and replicable neural signature of lifespan adversity in the adult brain
A stable and replicable neural signature of lifespan adversity in the adult brain
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Holz, N. E., Zabihi, M., Kia, S. M., Monninger, M., Aggensteiner, P.-M., Siehl, S., Floris, D. L., Bokde, A. L. W., Desrivières, S., Flor, H., Grigis, A., Garavan, H., Gowland, P., Heinz, A., Brühl, R., Martinot, J.-L., Martinot, M.-L. P., Orfanos, D. P., Paus, T., … et al. (2023). A stable and replicable neural signature of lifespan adversity in the adult brain. Nature Neuroscience, 26(9), 1603–1612. https://doi.org/10.1038/s41593-023-01410-8
Abstract
Abstract
Abstract
Environmental adversities constitute potent risk factors for psychiatric disorders. Evidence suggests the brain adapts to adversity, possibly in an adversity-type and region-specific manner. However, the long-term effects of adversity on brain structure and the association of individual neurobiological heterogeneity with behavior have yet to be elucidated. Here we estimated normative models of structural brain development based on a lifespan adversity profile in a longitudinal at-risk cohort aged 25 years (n = 169). This revealed wide
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Creators (Authors)
- Holz, Nathalie E
- Zabihi, Mariam
- Kia, Seyed Mostafa
- Monninger, Maximillian
- Aggensteiner, Pascal-M
- Siehl, Sebastian
- Floris, Dorothea L
- Bokde, Arun L W
- Desrivières, Sylvane
- Flor, Herta
- Grigis, Antoine
- Garavan, Hugh
- Gowland, Penny
- Heinz, Andreas
- Brühl, Rüdiger
- Martinot, Jean-Luc
- Martinot, Marie-Laure Paillère
- Orfanos, Dimitri Papadopoulos
- Paus, Tomáš
- Poustka, Luise
- Fröhner, Juliane H
- Smolka, Michael N
- Vaidya, Nilakshi
- Walter, Henrik
- Whelan, Robert
- Schumann, Gunter
- Meyer-Lindenberg, Andreas
- Brandeis, Daniel
- Buitelaar, Jan K
- Nees, Frauke
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Citations
Holz, N. E., Zabihi, M., Kia, S. M., Monninger, M., Aggensteiner, P.-M., Siehl, S., Floris, D. L., Bokde, A. L. W., Desrivières, S., Flor, H., Grigis, A., Garavan, H., Gowland, P., Heinz, A., Brühl, R., Martinot, J.-L., Martinot, M.-L. P., Orfanos, D. P., Paus, T., … et al. (2023). A stable and replicable neural signature of lifespan adversity in the adult brain. Nature Neuroscience, 26(9), 1603–1612. https://doi.org/10.1038/s41593-023-01410-8
