Publication: Membrane transporters control cerebrospinal fluid formation independently of conventional osmosis to modulate intracranial pressure
Membrane transporters control cerebrospinal fluid formation independently of conventional osmosis to modulate intracranial pressure
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Oernbo, E. K., Steffensen, A. B., Razzaghi Khamesi, P., Toft-Bertelsen, T. L., Barbuskaite, D., Vilhardt, F., Gerkau, N. J., Tritsaris, K., Simonsen, A. H., Lolansen, S. D., Andreassen, S. N., Hasselbalch, S. G., Zeuthen, T., Rose, C. R., Kurtcuoglu, V., & MacAulay, N. (2022). Membrane transporters control cerebrospinal fluid formation independently of conventional osmosis to modulate intracranial pressure. Fluids and Barriers of the CNS, 19(1), 65. https://doi.org/10.1186/s12987-022-00358-4
Abstract
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Abstract
Background: Disturbances in the brain fluid balance can lead to life-threatening elevation in the intracranial pressure (ICP), which represents a vast clinical challenge. Nevertheless, the details underlying the molecular mechanisms governing cerebrospinal fluid (CSF) secretion are largely unresolved, thus preventing targeted and efficient pharmaceutical therapy of cerebral pathologies involving elevated ICP. Methods: Experimental rats were employed for in vivo determinations of CSF secretion rates, ICP, blood pressure and ex vivo exc
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Creators (Authors)
- Oernbo, Eva K
- Steffensen, Annette B
- Razzaghi Khamesi, Pooya
- Toft-Bertelsen, Trine L
- Barbuskaite, Dagne
- Vilhardt, Frederik
- Gerkau, Niklas J
- Tritsaris, Katerina
- Simonsen, Anja H
- Lolansen, Sara D
- Andreassen, Søren N
- Hasselbalch, Steen G
- Zeuthen, Thomas
- Rose, Christine R
- MacAulay, Nanna
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Oernbo, E. K., Steffensen, A. B., Razzaghi Khamesi, P., Toft-Bertelsen, T. L., Barbuskaite, D., Vilhardt, F., Gerkau, N. J., Tritsaris, K., Simonsen, A. H., Lolansen, S. D., Andreassen, S. N., Hasselbalch, S. G., Zeuthen, T., Rose, C. R., Kurtcuoglu, V., & MacAulay, N. (2022). Membrane transporters control cerebrospinal fluid formation independently of conventional osmosis to modulate intracranial pressure. Fluids and Barriers of the CNS, 19(1), 65. https://doi.org/10.1186/s12987-022-00358-4
