Publication: Therapeutic miR-21 Silencing Ameliorates Diabetic Kidney Disease in Mice
Therapeutic miR-21 Silencing Ameliorates Diabetic Kidney Disease in Mice
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Kölling, M., Kaucsar, T., Schauerte, C., Hübner, A., Dettling, A., Park, J.-K., Busch, M., Wulff, X., Meier, M., Scherf, K., Bukosza, N., Szénási, G., Godó, M., Sharma, A., Heuser, M., Hamar, P., Bang, C., Haller, H., Thum, T., & Lorenzen, J. M. (2017). Therapeutic miR-21 Silencing Ameliorates Diabetic Kidney Disease in Mice. Molecular Therapy, 25, 165–180. https://doi.org/10.1016/j.ymthe.2016.08.001
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Abstract
Diabetic nephropathy is the main cause of end-stage renal disease. MicroRNAs are powerful regulators of the genome, and global expression profiling revealed miR-21 to be among the most highly regulated microRNAs in kidneys of mice with diabetic nephropathy. In kidney biopsies of diabetic patients, miR-21 correlated with tubulointerstitial injury. In situ PCR analysis showed a specific enrichment of miR-21 in glomerular cells. We identified cell division cycle 25a (Cdc25a) and cyclin-dependent kinase 6 (Cdk6) as novel miR-21 targets in
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- Kölling, Malte
- Kaucsar, Tamas
- Schauerte, Celina
- Hübner, Anika
- Dettling, Angela
- Park, Joon-Keun
- Busch, Martin
- Wulff, Xaver
- Meier, Matthias
- Scherf, Kristian
- Bukosza, Nóra
- Szénási, Gábor
- Godó, Mária
- Sharma, Amit
- Heuser, Michael
- Hamar, Peter
- Bang, Claudia
- Haller, Hermann
- Thum, Thomas
- Lorenzen, Johan M
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Kölling, M., Kaucsar, T., Schauerte, C., Hübner, A., Dettling, A., Park, J.-K., Busch, M., Wulff, X., Meier, M., Scherf, K., Bukosza, N., Szénási, G., Godó, M., Sharma, A., Heuser, M., Hamar, P., Bang, C., Haller, H., Thum, T., & Lorenzen, J. M. (2017). Therapeutic miR-21 Silencing Ameliorates Diabetic Kidney Disease in Mice. Molecular Therapy, 25, 165–180. https://doi.org/10.1016/j.ymthe.2016.08.001
