Quantitative CT texture analysis for diagnosing systemic sclerosis: Effect of iterative reconstructions and radiation doses

Milanese, Gianluca; Mannil, Manoj; Martini, Katharina; Maurer, Britta; Alkadhi, Hatem; Frauenfelder, Thomas

doi:10.1097/MD.0000000000016423

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Milanese, G., Mannil, M., Martini, K., Maurer, B., Alkadhi, H., & Frauenfelder, T. (2019). Quantitative CT texture analysis for diagnosing systemic sclerosis: Effect of iterative reconstructions and radiation doses. Medicine, 98(29), e16423. https://doi.org/10.1097/MD.0000000000016423

Abstract

To test whether texture analysis (TA) can discriminate between Systemic Sclerosis (SSc) and non-SSc patients in computed tomography (CT) with different radiation doses and reconstruction algorithms.In this IRB-approved retrospective study, 85 CT scans at different radiation doses [49 standard dose CT (SDCT) with a volume CT dose index (CTDIvol) of 4.86 ± 2.1 mGy and 36 low-dose (LDCT) with a CTDIvol of 2.5 ± 1.5 mGy] were selected; 61 patients had Ssc ("cases"), and 24 patients had no SSc ("controls"). CT scans were reconstructed with