Publication: Constructive connectomics: How neuronal axons get from here to there using gene-expression maps derived from their family trees
Constructive connectomics: How neuronal axons get from here to there using gene-expression maps derived from their family trees
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Kerstjens, S., Michel, G., & Douglas, R. J. (2022). Constructive connectomics: How neuronal axons get from here to there using gene-expression maps derived from their family trees. PLoS Computational Biology, 18(8), e1010382. https://doi.org/10.1371/journal.pcbi.1010382
Abstract
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During brain development, billions of axons must navigate over multiple spatial scales to reach specific neuronal targets, and so build the processing circuits that generate the intelligent behavior of animals. However, the limited information capacity of the zygotic genome puts a strong constraint on how, and which, axonal routes can be encoded. We propose and validate a mechanism of development that can provide an efficient encoding of this global wiring task. The key principle, confirmed through simulation, is that basic constraint
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- Kerstjens, Stan
- Michel, Gabriela
- Douglas, Rodney J
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Kerstjens, S., Michel, G., & Douglas, R. J. (2022). Constructive connectomics: How neuronal axons get from here to there using gene-expression maps derived from their family trees. PLoS Computational Biology, 18(8), e1010382. https://doi.org/10.1371/journal.pcbi.1010382
