A conserved module regulates receptor kinase signalling in immunity and development

DeFalco, Thomas A; Anne, Pauline; James, Sean R; Willoughby, Andrew C; Schwanke, Florian; Johanndrees, Oliver; Genolet, Yasmine; Derbyshire, Paul; Wang, Qian; Rana, Surbhi; Pullen, Anne-Marie; Menke, Frank L H; Zipfel, Cyril; Hardtke, Christian S; Nimchuk, Zachary L

doi:10.5167/uzh-218551

Citations

Citation copied

DeFalco, T. A., Anne, P., James, S. R., Willoughby, A. C., Schwanke, F., Johanndrees, O., Genolet, Y., Derbyshire, P., Wang, Q., Rana, S., Pullen, A.-M., Menke, F. L. H., Zipfel, C., Hardtke, C. S., & Nimchuk, Z. L. (2022). A conserved module regulates receptor kinase signalling in immunity and development. Nature Plants, 8(4), 356–365. https://doi.org/10.1038/s41477-022-01134-w

Abstract

Ligand recognition by cell-surface receptors underlies development and immunity in both animals and plants. Modulating receptor signalling is critical for appropriate cellular responses but the mechanisms ensuring this are poorly understood. Here, we show that signalling by plant receptors for pathogen-associated molecular patterns (PAMPs) in immunity and CLAVATA3/EMBRYO SURROUNDING REGION-RELATED peptides (CLEp) in development uses a similar regulatory module. In the absence of ligand, signalling is dampened through association with