Publication: Effects of mannitol bolus administration on intracranial pressure, cerebral extracellular metabolites, and tissue oxygenation in severely head-injured patients
Effects of mannitol bolus administration on intracranial pressure, cerebral extracellular metabolites, and tissue oxygenation in severely head-injured patients
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Sakowitz, O. W., Stover, J. F., Sarrafzadeh, A. S., Unterberg, A. W., & Kiening, K. L. (2007). Effects of mannitol bolus administration on intracranial pressure, cerebral extracellular metabolites, and tissue oxygenation in severely head-injured patients. Journal of Trauma - Injury Infection & Critical Care, 62(2), 292–298. https://doi.org/10.1097/01.ta.0000203560.03937.2d
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BACKGROUND: Osmotic agents are widely used to lower elevated intracranial pressure (ICP). However, little data are available regarding cerebral oxygenation and metabolism in the traumatized brains studied under clinical conditions. The present prospective, open-labeled clinical study was designed to investigate whether administration of mannitol, with the aim of reducing moderate intracranial hypertension, improves cerebral metabolism and oxygenation in patients after severe traumatic brain injury (TBI). METHODS: Multimodal cerebral m
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- Sakowitz, O W
- Stover, J F
- Sarrafzadeh, A S
- Unterberg, A W
- Kiening, K L
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Sakowitz, O. W., Stover, J. F., Sarrafzadeh, A. S., Unterberg, A. W., & Kiening, K. L. (2007). Effects of mannitol bolus administration on intracranial pressure, cerebral extracellular metabolites, and tissue oxygenation in severely head-injured patients. Journal of Trauma - Injury Infection & Critical Care, 62(2), 292–298. https://doi.org/10.1097/01.ta.0000203560.03937.2d
