Publication: Iron accelerates hemoglobin oxidation increasing mortality in vascular diseased guinea pigs following transfusion of stored blood
Iron accelerates hemoglobin oxidation increasing mortality in vascular diseased guinea pigs following transfusion of stored blood
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Baek, J. H., Yalamanoglu, A., Gao, Y., Guenster, R., Spahn, D. R., Schaer, D. J., & Buehler, P. W. (2017). Iron accelerates hemoglobin oxidation increasing mortality in vascular diseased guinea pigs following transfusion of stored blood. Journal of Clinical Investigation Insight, 2, 93577. https://doi.org/10.1172/jci.insight.93577
Abstract
Abstract
Abstract
Non-transferrin-bound iron (NTBI) and free hemoglobin (Hb) accumulate in circulation following stored RBC transfusions. This study investigated transfusion, vascular disease, and mortality in guinea pigs after stored RBC transfusion alone and following cotransfusion with apo-transferrin (apo-Tf) and haptoglobin (Hp). The effects of RBC exchange transfusion dose (1, 3, and 9 units), storage period (14 days), and mortality were evaluated in guinea pigs with a vascular disease phenotype. Seven-day mortality and the interaction between ir
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Creators (Authors)
- Baek, Jin Hyen
- Yalamanoglu, Ayla
- Gao, Yamei
- Guenster, Ricardo
- Spahn, Donat R
- Schaer, Dominik J
- Buehler, Paul W
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Citations
Baek, J. H., Yalamanoglu, A., Gao, Y., Guenster, R., Spahn, D. R., Schaer, D. J., & Buehler, P. W. (2017). Iron accelerates hemoglobin oxidation increasing mortality in vascular diseased guinea pigs following transfusion of stored blood. Journal of Clinical Investigation Insight, 2, 93577. https://doi.org/10.1172/jci.insight.93577
