Publication: Cryo-electron tomography reveals four-membrane architecture of the Plasmodium apicoplast
Cryo-electron tomography reveals four-membrane architecture of the Plasmodium apicoplast
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Lemgruber, L., Kudryashev, M., Dekiwadia, C., Riglar, D. T., Baum, J., Stahlberg, H., Ralph, S. A., & Frischknecht, F. (2013). Cryo-electron tomography reveals four-membrane architecture of the Plasmodium apicoplast. Malaria Journal, 12, 25. https://doi.org/10.1186/1475-2875-12-25
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Background: The apicoplast is a plastid organelle derived from a secondary endosymbiosis, containing biosynthetic pathways essential for the survival of apicomplexan parasites. The Toxoplasma apicoplast clearly possesses four membranes but in related Plasmodium spp. the apicoplast has variably been reported to have either three or four membranes. Methods: Cryo-electron tomography was employed to image merozoites of Plasmodium falciparum and Plasmodium berghei frozen in their near-native state. Three-dimensional reconstructions reveale
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- Lemgruber, Leandro
- Kudryashev, Mikhail
- Dekiwadia, Chaitali
- Riglar, David T
- Baum, Jake
- Stahlberg, Henning
- Ralph, Stuart A
- Frischknecht, Friedrich
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Lemgruber, L., Kudryashev, M., Dekiwadia, C., Riglar, D. T., Baum, J., Stahlberg, H., Ralph, S. A., & Frischknecht, F. (2013). Cryo-electron tomography reveals four-membrane architecture of the Plasmodium apicoplast. Malaria Journal, 12, 25. https://doi.org/10.1186/1475-2875-12-25
