Publication: Epidermal Growth Factor Signaling Promotes Sleep through a Combined Series and Parallel Neural Circuit
Epidermal Growth Factor Signaling Promotes Sleep through a Combined Series and Parallel Neural Circuit
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Konietzka, J., Fritz, M., Spiri, S., McWhirter, R., Leha, A., Palumbos, S., Costa, W. S., Oranth, A., Gottschalk, A., Miller, D. M., Hajnal, A., & Bringmann, H. (2020). Epidermal Growth Factor Signaling Promotes Sleep through a Combined Series and Parallel Neural Circuit. Current Biology, 30(1), 1-16.e13. https://doi.org/10.1016/j.cub.2019.10.048
Abstract
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Abstract
Sleep requires sleep-active neurons that depolarize to inhibit wake circuits. Sleep-active neurons are under the control of homeostatic mechanisms that determine sleep need. However, little is known about the molecular and circuit mechanisms that translate sleep need into the depolarization of sleep-active neurons. During many stages and conditions in C. elegans, sleep requires a sleep-active neuron called RIS. Here, we defined the transcriptome of RIS and discovered that genes of the epidermal growth factor receptor (EGFR) signaling
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- Konietzka, Jan
- Fritz, Maximilian
- McWhirter, Rebecca
- Leha, Andreas
- Palumbos, Sierra
- Costa, Wagner Steuer
- Oranth, Alexandra
- Gottschalk, Alexander
- Miller, David M
- Bringmann, Henrik
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Konietzka, J., Fritz, M., Spiri, S., McWhirter, R., Leha, A., Palumbos, S., Costa, W. S., Oranth, A., Gottschalk, A., Miller, D. M., Hajnal, A., & Bringmann, H. (2020). Epidermal Growth Factor Signaling Promotes Sleep through a Combined Series and Parallel Neural Circuit. Current Biology, 30(1), 1-16.e13. https://doi.org/10.1016/j.cub.2019.10.048