Publication: Immunohistochemical PSMA expression patterns of primary prostate cancer tissue are associated with the detection rate of biochemical recurrence with 68Ga-PSMA-11-PET
Immunohistochemical PSMA expression patterns of primary prostate cancer tissue are associated with the detection rate of biochemical recurrence with 68Ga-PSMA-11-PET
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Ferraro, D. A., Rüschoff, J. H., Muehlematter, U. J., Kranzbühler, B., Müller, J., Messerli, M., Husmann, L., Hermanns, T., Eberli, D., Rupp, N. J., & Burger, I. A. (2020). Immunohistochemical PSMA expression patterns of primary prostate cancer tissue are associated with the detection rate of biochemical recurrence with 68Ga-PSMA-11-PET. Theranostics, 10(14), 6082–6094. https://doi.org/10.7150/thno.44584
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Abstract
Prostate-specific membrane antigen (PSMA) targeted PET has a high detection rate for biochemical recurrence (BCR) of prostate cancer (PCa). Nevertheless, even at high prostate-specific antigen (PSA) levels (> 3 ng/ml), a relevant number of PSMA-PET scans are negative, mainly due to PSMA-negative PCa. Our objective was to investigate whether PSMA-expression patterns of the primary tumour on immunohistochemistry (IHC) are associated with PSMA-PET detection rate of recurrent PCa. Methods: Retrospective institutional review board approved
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Ferraro, D. A., Rüschoff, J. H., Muehlematter, U. J., Kranzbühler, B., Müller, J., Messerli, M., Husmann, L., Hermanns, T., Eberli, D., Rupp, N. J., & Burger, I. A. (2020). Immunohistochemical PSMA expression patterns of primary prostate cancer tissue are associated with the detection rate of biochemical recurrence with 68Ga-PSMA-11-PET. Theranostics, 10(14), 6082–6094. https://doi.org/10.7150/thno.44584