Publication: Protease-activated receptor-1 cleaved at R46 mediates cytoprotective effects
Protease-activated receptor-1 cleaved at R46 mediates cytoprotective effects
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Schuepbach, R. A., Madon, J., Ender, M., Galli, P., & Riewald, M. (2012). Protease-activated receptor-1 cleaved at R46 mediates cytoprotective effects. Journal of Thrombosis and Haemostasis, 10(8), 1675–1684. https://doi.org/10.1111/j.1538-7836.2012.04825.x
Abstract
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Abstract
BACKGROUND: Activated protein C (aPC) mediates powerful cytoprotective effects through the protease-activated receptor-1 (PAR1) that translate into reduced harm in mouse injury models. However, it remains elusive how aPC-activated PAR1 can mediate cytoprotective effects whereas thrombin activation does the opposite. OBJECTIVES: We hypothesized that aPC and thrombin might induce distinct active conformations in PAR1 causing opposing effects. METHODS: We analyzed antibody binding to, and cleavage and signalling of PAR1 in either endog
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- Schuepbach, R A
- Madon, J
- Ender, M
- Galli, P
- Riewald, M
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Schuepbach, R. A., Madon, J., Ender, M., Galli, P., & Riewald, M. (2012). Protease-activated receptor-1 cleaved at R46 mediates cytoprotective effects. Journal of Thrombosis and Haemostasis, 10(8), 1675–1684. https://doi.org/10.1111/j.1538-7836.2012.04825.x
