Immunological and tumor-intrinsic mechanisms mediate the synergistic growth suppression of experimental glioblastoma by radiotherapy and MET inhibition

Silginer, Manuela; Papa, Eleanna; Szabó, Emese; Vasella, Flavio; Pruschy, Martin; Stroh, Christopher; Roth, Patrick; Weiss, Tobias; Weller, Michael

doi:10.1186/s40478-023-01527-8

Citations

Citation copied

Silginer, M., Papa, E., Szabó, E., Vasella, F., Pruschy, M., Stroh, C., Roth, P., Weiss, T., & Weller, M. (2023). Immunological and tumor-intrinsic mechanisms mediate the synergistic growth suppression of experimental glioblastoma by radiotherapy and MET inhibition. Acta Neuropathologica Communications, 11(1), 41. https://doi.org/10.1186/s40478-023-01527-8

Abstract

The hepatocyte growth factor (HGF)/MET signaling pathway has been proposed to be involved in the resistance to radiotherapy of glioblastoma via proinvasive and DNA damage response pathways.Here we assessed the role of the MET pathway in the response to radiotherapy in vitro and in vivo in syngeneic mouse glioma models. We find that the murine glioma cell lines GL-261, SMA-497, SMA-540 and SMA-560 express HGF and its receptor MET and respond to exogenous HGF with MET phosphorylation. Glioma cell viability or proliferation are unaffecte