Publication: PARP7 Regulates FRA1 Protein-Turnover and Thermostability: Implications for Cancer Progression and Treatment
PARP7 Regulates FRA1 Protein-Turnover and Thermostability: Implications for Cancer Progression and Treatment
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Manetsch, P. (2024). PARP7 Regulates FRA1 Protein-Turnover and Thermostability: Implications for Cancer Progression and Treatment. (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-259337
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Post-translational modifications (PTMs) profoundly impact protein function and are involved in almost all cell biological processes. Various PTMs, including ADP-ribosylation, have also been linked to different pathologies such as cancer. The discovery of the synthetic lethal interaction between PARP1 inhibitors and BRCA-deficient tumors has led to the development of ADP-ribosylation inhibitors as a novel class of anticancer drugs. This has highlighted the potential of ADP-ribosyltransferases as targets for cancer therapy. Recently, it
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Manetsch, P. (2024). PARP7 Regulates FRA1 Protein-Turnover and Thermostability: Implications for Cancer Progression and Treatment. (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-259337
