Publication: Obesity and aging: determinants of endothelial cell dysfunction and atherosclerosis
Obesity and aging: determinants of endothelial cell dysfunction and atherosclerosis
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Barton, M. (2010). Obesity and aging: determinants of endothelial cell dysfunction and atherosclerosis. Pflügers Archiv : European Journal of Physiology, 460(5), 825–837. https://doi.org/10.1007/s00424-010-0860-y
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Endothelial cells are both the source and target of factors contributing to atherosclerosis. After the discovery of the endothelium-derived relaxing factor (EDRF) by Robert F. Furchgott in 1980 it soon became clear that endothelial cells also release vasoactive factors distinct from nitric oxide (NO) namely, endothelium-derived contracting factors (EDCF) as well as hyperpolarizing factors (EDHF). Vasoactive factors derived from endothelial cells include NO/EDRF, reactive oxygen species, endothelins and angiotensins which have either E
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- Barton, Matthias
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Barton, M. (2010). Obesity and aging: determinants of endothelial cell dysfunction and atherosclerosis. Pflügers Archiv : European Journal of Physiology, 460(5), 825–837. https://doi.org/10.1007/s00424-010-0860-y
