Publication: TGFbeta receptor II gene deletion in leucocytes prevents cerebral vasculitis in bacterial meningitis
TGFbeta receptor II gene deletion in leucocytes prevents cerebral vasculitis in bacterial meningitis
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Malipiero, U., Koedel, U., Pfister, H. W., Levéen, P., Bürki, K., Reith, W., & Fontana, A. (2006). TGFbeta receptor II gene deletion in leucocytes prevents cerebral vasculitis in bacterial meningitis. Brain : A Journal of Neurology, 129(9), 2404–2415. https://doi.org/10.1093/brain/awl192
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Abstract
In bacterial meningitis, chemokines lead to recruitment of polymorphonuclear leucocytes (PMN) into the CNS. At the site of infection in the subarachnoid space, PMN release reactive oxygen species, reactive nitrogen intermediates (RNI) and interleukin-1beta (IL-1beta). Although these immune factors assist in clearance of bacteria, they also result in neuronal injury associated with meningitis. Transforming growth factor beta (TGFbeta) is a potent deactivator of PMN and macrophages since TGFbeta suppresses the production of ROI, RNI and
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- Malipiero, U
- Koedel, U
- Pfister, H W
- Levéen, P
- Bürki, K
- Reith, W
- Fontana, A
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Malipiero, U., Koedel, U., Pfister, H. W., Levéen, P., Bürki, K., Reith, W., & Fontana, A. (2006). TGFbeta receptor II gene deletion in leucocytes prevents cerebral vasculitis in bacterial meningitis. Brain : A Journal of Neurology, 129(9), 2404–2415. https://doi.org/10.1093/brain/awl192
