Publication: WNT ligands control initiation and progression of human papillomavirus-driven squamous cell carcinoma
WNT ligands control initiation and progression of human papillomavirus-driven squamous cell carcinoma
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Zimmerli, D., Cecconi, V., Valenta, T., Hausmann, G., Cantù, C., Restivo, G., Hafner, J., Basler, K., & van den Broek, M. (2018). WNT ligands control initiation and progression of human papillomavirus-driven squamous cell carcinoma. Oncogene, 37, 3753–3762. https://doi.org/10.1038/s41388-018-0244-x
Abstract
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Abstract
Human papillomavirus (HPV)-driven cutaneous squamous cell carcinoma (cSCC) is the most common cancer in immunosuppressed patients. Despite indications suggesting that HPV promotes genomic instability during cSCC development, the molecular pathways underpinning HPV-driven cSCC development remain unknown. We compared the transcriptome of HPV-driven mouse cSCC with normal skin and observed higher amounts of transcripts for Porcupine and WNT ligands in cSCC, suggesting a role for WNT signaling in cSCC progression. We confirmed increased P
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- Zimmerli, Dario
- Cecconi, Virginia
- Valenta, Tomas
- Hausmann, George
- Cantù, Claudio
- Restivo, Gaetana
- Hafner, Jürg
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Zimmerli, D., Cecconi, V., Valenta, T., Hausmann, G., Cantù, C., Restivo, G., Hafner, J., Basler, K., & van den Broek, M. (2018). WNT ligands control initiation and progression of human papillomavirus-driven squamous cell carcinoma. Oncogene, 37, 3753–3762. https://doi.org/10.1038/s41388-018-0244-x
