Publication: Homology modeling and dynamics of the extracellular domain of rat and human neuronal nicotinic acetylcholine receptor subtypes α4β2 and α7
Homology modeling and dynamics of the extracellular domain of rat and human neuronal nicotinic acetylcholine receptor subtypes α4β2 and α7
Date
Date
Date
Citations
Bisson, W. H., Westera, G., Schubiger, P. A., & Scapozza, L. (2008). Homology modeling and dynamics of the extracellular domain of rat and human neuronal nicotinic acetylcholine receptor subtypes α4β2 and α7. Journal of Molecular Modeling, 14(10), 891–899. https://doi.org/10.1007/s00894-008-0340-x
Abstract
Abstract
Abstract
In recent years, it has become clear that the neuronal nicotinic acetylcholine receptor (nAChR) is a valid target in the treatment of a variety of diseases, including Alzheimer's disease, anxiety, and nicotine addiction. As with most membrane proteins, information on the three-dimensional (3D) structure of nAChR is limited to data from electron microscopy, at a resolution that makes the application of structure-based design approaches to develop specific ligands difficult. Based on a high-resolution crystal structure of AChBP, homolog
Metrics
Downloads
Views
Additional indexing
Creators (Authors)
- Bisson, William H
- Westera, Gerrit
- Schubiger, P Augustus
- Scapozza, Leonardo
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Page end
Page end
Page end
Item Type
Item Type
Item Type
In collections
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Publisher DOI
Metrics
Downloads
Views
Citations
Bisson, W. H., Westera, G., Schubiger, P. A., & Scapozza, L. (2008). Homology modeling and dynamics of the extracellular domain of rat and human neuronal nicotinic acetylcholine receptor subtypes α4β2 and α7. Journal of Molecular Modeling, 14(10), 891–899. https://doi.org/10.1007/s00894-008-0340-x
