Publication: Microfluidic Preparation of 89Zr-Radiolabelled Proteins by Flow Photochemistry
Microfluidic Preparation of 89Zr-Radiolabelled Proteins by Flow Photochemistry
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Earley, D. F., Guillou, A., van der Born, D., Poot, A. J., & Holland, J. P. (2021). Microfluidic Preparation of 89Zr-Radiolabelled Proteins by Flow Photochemistry. Molecules, 26(3), 764. https://doi.org/10.3390/molecules26030764
Abstract
Abstract
Abstract
89Zr-radiolabelled proteins functionalised with desferrioxamine B are a cornerstone of diagnostic positron emission tomography. In the clinical setting, 89Zr-labelled proteins are produced manually. Here, we explore the potential of using a microfluidic photochemical flow reactor to prepare 89Zr-radiolabelled proteins. The light-induced functionalisation and 89Zr-radiolabelling of human serum albumin ([89Zr]ZrDFO-PEG3-Et-azepin-HSA) was achieved by flow photochemistry with a decay-corrected radiochemical yield (RCY) of 31.2 ± 1.3% (n
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- Earley, Daniel F
- Guillou, Amaury
- Poot, Alex J
- Holland, Jason P
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Citations
Earley, D. F., Guillou, A., van der Born, D., Poot, A. J., & Holland, J. P. (2021). Microfluidic Preparation of 89Zr-Radiolabelled Proteins by Flow Photochemistry. Molecules, 26(3), 764. https://doi.org/10.3390/molecules26030764
