Publication: Insights into the Activation and Heteromerization of LRRC8A/C Volume-Regulated Anion Channels
Insights into the Activation and Heteromerization of LRRC8A/C Volume-Regulated Anion Channels
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Rutz, S. (2024). Insights into the Activation and Heteromerization of LRRC8A/C Volume-Regulated Anion Channels. (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-258663
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Volume-regulated anion channels (VRACs) are key players in cell volume regulation and are involved in a variety of physiological processes. VRACs are composed of LRRC8 proteins, a protein family with five paralogs, termed LRRC8A, B, C, D and E. In a cellular environment, functional VRACs assemble as heteromeric channels containing LRRC8A and at least one other LRRC8 protein. Homomeric LRRC8A proteins assemble into hexameric channels but show reduced activity. The high-resolution structure of homomeric LRRC8A channels has revealed a mo
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Rutz, S. (2024). Insights into the Activation and Heteromerization of LRRC8A/C Volume-Regulated Anion Channels. (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-258663
