Human genomics of acute liver failure due to hepatitis B virus infection: An exome sequencing study in liver transplant recipients

Asgari, Samira; Chaturvedi, Nimisha; Scepanovic, Petar; Hämmerle, Christian; Semmo, Nasser; Giostra, Emiliano; Müllhaupt, Beat; Angus, Peter; Thompson, Alexander J; Moradpour, Darius; Fellay, Jacques

doi:10.1111/jvh.13019

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Asgari, S., Chaturvedi, N., Scepanovic, P., Hämmerle, C., Semmo, N., Giostra, E., Müllhaupt, B., Angus, P., Thompson, A. J., Moradpour, D., & Fellay, J. (2019). Human genomics of acute liver failure due to hepatitis B virus infection: An exome sequencing study in liver transplant recipients. Journal of Viral Hepatitis, 26(2), 271–277. https://doi.org/10.1111/jvh.13019

Abstract

Acute liver failure (ALF) or fulminant hepatitis is a rare, yet severe outcome of infection with hepatitis B virus (HBV) that carries a high mortality rate. The occurrence of a life-threatening condition upon infection with a prevalent virus in individuals without known risk factors is suggestive of pathogen-specific immune dysregulation. In the absence of established differences in HBV virulence, we hypothesized that ALF upon primary infection with HBV could be due to rare deleterious variants in the human genome. To search for such