Publication: Interaction of HIV protease inhibitors with OATP1B1, 1B3, and 2B1
Interaction of HIV protease inhibitors with OATP1B1, 1B3, and 2B1
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Annaert, P., Ye, Z. W., Stieger, B., & Augustijns, P. (2010). Interaction of HIV protease inhibitors with OATP1B1, 1B3, and 2B1. Xenobiotica, 40(3), 163–176. https://doi.org/10.3109/00498250903509375
Abstract
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The effects of human immunodeficiency virus (HIV) protease inhibitors (PI) on the accumulation of the fluorescent bile salt analogue cholyl-glycylamido-fluorescein (CGamF) were determined in organic anion transporting polypeptide (OATP)-1B1 and -1B3-expressing Chinese hamster ovary (CHO) cells. In addition, interaction studies in Caco-2 monolayers, known only to express the OATP2B1 isoform, were conducted using the established OATP substrate estrone 3-sulfate (E3S), since no CGamF accumulation was observed in Caco-2 monolayers. CGamF
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- Annaert, P
- Ye, Z W
- Stieger, B
- Augustijns, P
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Annaert, P., Ye, Z. W., Stieger, B., & Augustijns, P. (2010). Interaction of HIV protease inhibitors with OATP1B1, 1B3, and 2B1. Xenobiotica, 40(3), 163–176. https://doi.org/10.3109/00498250903509375
