Publication: Type 2 immune predisposition results in accelerated neutrophil aging causing susceptibility to bacterial infection
Type 2 immune predisposition results in accelerated neutrophil aging causing susceptibility to bacterial infection
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Egholm, C., Özcan, A., Breu, D., & Boyman, O. (2022). Type 2 immune predisposition results in accelerated neutrophil aging causing susceptibility to bacterial infection. Science Immunology, 71, eabi9733. https://doi.org/10.1126/sciimmunol.abi9733
Abstract
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Atopic individuals show enhanced type 2 immune cell responses and a susceptibility to infections with certain bacteria and viruses. Although patients with allergic diseases harbor normal counts of circulating neutrophils, these cells exert deficient effector functions. However, the underlying mechanism of this dysregulation of neutrophils remains ill defined. Here, we find that development, aging, and elimination of neutrophils are accelerated in mice with a predisposition to type 2 immunity, which, in turn, causes susceptibility to i
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- Egholm, Cecilie
- Özcan, Alaz
- Breu, Daniel
- Boyman, Onur
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Egholm, C., Özcan, A., Breu, D., & Boyman, O. (2022). Type 2 immune predisposition results in accelerated neutrophil aging causing susceptibility to bacterial infection. Science Immunology, 71, eabi9733. https://doi.org/10.1126/sciimmunol.abi9733