Publication: A mouse model for the human pathogen Salmonella typhi
A mouse model for the human pathogen Salmonella typhi
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Song, J., Willinger, T., Rongvaux, A., Eynon, E. E., Stevens, S., Manz, M. G., Flavell, R. A., & Galán, J. E. (2010). A mouse model for the human pathogen Salmonella typhi. Cell Host & Microbe, 8, 369–376. https://doi.org/10.1016/j.chom.2010.09.003
Abstract
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Abstract
Salmonella enterica serovar Typhi (S. Typhi) causes typhoid fever, a life-threatening human disease. The lack of animal models due to S. Typhi's strict human host specificity has hindered its study and vaccine development. We find that immunodeficient Rag2(-/-) γc(-/-) mice engrafted with human fetal liver hematopoietic stem and progenitor cells are able to support S. Typhi replication and persistent infection. A S. Typhi mutant in a gene required for virulence in humans was unable to replicate in these mice. Another mutant unable to
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- Song, J
- Willinger, T
- Rongvaux, A
- Eynon, E E
- Stevens, S
- Manz, M G
- Flavell, R A
- Galán, J E
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Song, J., Willinger, T., Rongvaux, A., Eynon, E. E., Stevens, S., Manz, M. G., Flavell, R. A., & Galán, J. E. (2010). A mouse model for the human pathogen Salmonella typhi. Cell Host & Microbe, 8, 369–376. https://doi.org/10.1016/j.chom.2010.09.003
