Publication: Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing
Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing
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Romao, S., Gasser, N., Becker, A. C., Guhl, B., Bajagic, M., Vanoaica, D., Ziegler, U., Roesler, J., Dengjel, J., Reichenbach, J., & Münz, C. (2013). Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing. Journal of Cell Biology, 203(5), 757–766. https://doi.org/10.1083/jcb.201308173
Abstract
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Abstract
Antigen preservation for presentation is a hallmark of potent antigen-presenting cells. In this paper, we report that in human macrophages and dendritic cells, a subset of phagosomes gets coated with Atg8/LC3, a component of the molecular machinery of macroautophagy, and maintains phagocytosed antigens for prolonged presentation on major histocompatibility complex class II molecules. These Atg8/LC3-positive phagosomes are formed around the antigen with TLR2 agonists and require reactive oxygen species production by NOX2 for their gene
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- Romao, Susana
- Gasser, Nathalie
- Becker, Andrea C
- Guhl, Bruno
- Bajagic, Milica
- Vanoaica, Danusia
- Ziegler, Urs
- Roesler, Joachim
- Dengjel, Jörn
- Reichenbach, Janine
- Münz, Christian
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Romao, S., Gasser, N., Becker, A. C., Guhl, B., Bajagic, M., Vanoaica, D., Ziegler, U., Roesler, J., Dengjel, J., Reichenbach, J., & Münz, C. (2013). Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing. Journal of Cell Biology, 203(5), 757–766. https://doi.org/10.1083/jcb.201308173
