Publication: Influence of Scaffold Microarchitecture on Angiogenesis and Regulation of Cell Differentiation during the Early Phase of Bone Healing: A Transcriptomics and Histological Analysis
Influence of Scaffold Microarchitecture on Angiogenesis and Regulation of Cell Differentiation during the Early Phase of Bone Healing: A Transcriptomics and Histological Analysis
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Guerrero, J., Maevskaia, E., Ghayor, C., Bhattacharya, I., & Weber, F. E. (2023). Influence of Scaffold Microarchitecture on Angiogenesis and Regulation of Cell Differentiation during the Early Phase of Bone Healing: A Transcriptomics and Histological Analysis. International Journal of Molecular Sciences, 24(6), 6000. https://doi.org/10.3390/ijms24066000
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The early phase of bone healing is a complex and poorly understood process. With additive manufacturing, we can generate a specific and customizable library of bone substitutes to explore this phase. In this study, we produced tricalcium phosphate-based scaffolds with microarchitectures composed of filaments of 0.50 mm in diameter, named Fil050G, and 1.25 mm named Fil125G, respectively. The implants were removed after only 10 days in vivo followed by RNA sequencing (RNAseq) and histological analysis. RNAseq results revealed upregulati
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- Guerrero, Julien
- Maevskaia, Ekaterina
- Ghayor, Chafik
- Bhattacharya, Indranil
- Weber, Franz E
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Guerrero, J., Maevskaia, E., Ghayor, C., Bhattacharya, I., & Weber, F. E. (2023). Influence of Scaffold Microarchitecture on Angiogenesis and Regulation of Cell Differentiation during the Early Phase of Bone Healing: A Transcriptomics and Histological Analysis. International Journal of Molecular Sciences, 24(6), 6000. https://doi.org/10.3390/ijms24066000
