Publication: Strain-Resolved Dynamics of the Lung Microbiome in Patients with Cystic Fibrosis
Strain-Resolved Dynamics of the Lung Microbiome in Patients with Cystic Fibrosis
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Dmitrijeva, M., Kahlert, C. R., Feigelman, R., Kleiner, R. L., Nolte, O., Albrich, W. C., Baty, F., & von Mering, C. (2021). Strain-Resolved Dynamics of the Lung Microbiome in Patients with Cystic Fibrosis. MBio, 12(2), e02863-20. https://doi.org/10.1128/mBio.02863-20
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In cystic fibrosis, dynamic and complex communities of microbial pathogens and commensals can colonize the lung. Cultured isolates from lung sputum reveal high inter- and intraindividual variability in pathogen strains, sequence variants, and phenotypes; disease progression likely depends on the precise combination of infecting lineages. Routine clinical protocols, however, provide a limited overview of the colonizer populations. Therefore, a more comprehensive and precise identification and characterization of infecting lineages coul
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Dmitrijeva, M., Kahlert, C. R., Feigelman, R., Kleiner, R. L., Nolte, O., Albrich, W. C., Baty, F., & von Mering, C. (2021). Strain-Resolved Dynamics of the Lung Microbiome in Patients with Cystic Fibrosis. MBio, 12(2), e02863-20. https://doi.org/10.1128/mBio.02863-20