Publication: Simultaneous interaction of enzymes with two modifiers: reappraisal of kinetic models and new paradigms
Simultaneous interaction of enzymes with two modifiers: reappraisal of kinetic models and new paradigms
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Schenker, P., & Baici, A. (2009). Simultaneous interaction of enzymes with two modifiers: reappraisal of kinetic models and new paradigms. Journal of Theoretical Biology, 261, 318–329. https://doi.org/10.1016/j.jtbi.2009.07.033
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Enzyme activity can be modulated by the concurrent action of two modifiers, either activators or inhibitors. The kinetic mechanisms for the interaction of the individual modifiers with the target enzyme can change considerably when two modifiers bind simultaneously. We illustrate a general equation for this kind of interactions, which can unambiguously describe the behavior of activators and inhibitors acting by any combination of classical kinetic mechanisms. The flexibility of this model is exemplified by combinations of activators
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- Schenker, Patricia
- Baici, Antonio
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Schenker, P., & Baici, A. (2009). Simultaneous interaction of enzymes with two modifiers: reappraisal of kinetic models and new paradigms. Journal of Theoretical Biology, 261, 318–329. https://doi.org/10.1016/j.jtbi.2009.07.033
