SARS-CoV-2 infection and its effects on the endocrine system

Steenblock, Charlotte; Toepfner, Nicole; Beuschlein, Felix; Perakakis, Nikolaos; Mohan Anjana, Ranjit; Mohan, Viswanathan; Mahapatra, Nitish R; Bornstein, Stefan R

doi:10.1016/j.beem.2023.101761

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Steenblock, C., Toepfner, N., Beuschlein, F., Perakakis, N., Mohan Anjana, R., Mohan, V., Mahapatra, N. R., & Bornstein, S. R. (2023). SARS-CoV-2 infection and its effects on the endocrine system. Best Practice & Research : Clinical Endocrinology & Metabolism, 37(4), 101761. https://doi.org/10.1016/j.beem.2023.101761

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing corona virus disease 2019 (COVID-19) can infect multiple tissues, including endocrine organs, such as the pancreas, adrenal, thyroid, and adipose tissue. The main receptor for SARS-CoV-2, ACE2, is ubiquitously expressed in the cells of the endocrine organs and accordingly, the virus has been detected in various amounts in all endocrine tissues in post-mortem samples from COVID-19 patients. The infection with SARS-CoV-2 may directly lead to organ damage or dysfunc