Publication: Uninephrectomy augments the effects of high fat diet induced obesity on gene expression in mouse kidney
Uninephrectomy augments the effects of high fat diet induced obesity on gene expression in mouse kidney
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Gai, Z., Hiller, C., Chin, S. H., Hofstetter, L., Stieger, B., Konrad, D., & Kullak-Ublick, G. A. (2014). Uninephrectomy augments the effects of high fat diet induced obesity on gene expression in mouse kidney. Biochimica et Biophysica Acta, 1842(9), 1870–1878. https://doi.org/10.1016/j.bbadis.2014.07.001
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Obesity has been reported as an independent risk factor for chronic kidney disease, leading to glomerulosclerosis and renal insufficiency. To assess the relationship between a reduced nephron number and a particular susceptibility to obesity-induced renal damage, mice underwent uninephrectomy (UNX) followed by either normal chow or high-fat diet (HFD) and were compared with sham-operated control mice. After 20 weeks of dietary intervention, HFD-fed control mice presented characteristic features of progressive nephropathy, including al
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- Gai, Zhibo
- Hiller, Christian
- Chin, Siew Hung
- Hofstetter, Lia
- Stieger, Bruno
- Kullak-Ublick, Gerd A
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Gai, Z., Hiller, C., Chin, S. H., Hofstetter, L., Stieger, B., Konrad, D., & Kullak-Ublick, G. A. (2014). Uninephrectomy augments the effects of high fat diet induced obesity on gene expression in mouse kidney. Biochimica et Biophysica Acta, 1842(9), 1870–1878. https://doi.org/10.1016/j.bbadis.2014.07.001
