Publication:

Effect of APOE ɛ4 Status on Brain Amyloid-β and Cognitive Function in Amnestic and Nonamnestic Mild Cognitive Impairment: A 18F Florbetapir PET-CT Study

Date

Date

Date
2024
Journal Article
Published version

Citations

Citation copied

Wang, M., Zhang, Z., Wang, Y., Huang, L., Huang, Q., Ren, S., Qian, L., Ni, R., Guo, Q., Guan, Y., & Xie, F. (2024). Effect of APOE ɛ4 Status on Brain Amyloid-β and Cognitive Function in Amnestic and Nonamnestic Mild Cognitive Impairment: A 18F Florbetapir PET-CT Study. Advanced Therapeutics, 7, 2400008. https://doi.org/10.1002/adtp.202400008

Abstract

Abstract

Abstract

Mild cognitive impairment (MCI) is recognized as a predementia syndrome caused by multiple etiologies and nonmemory symptoms in MCI have recently gained increasing attention. However, the pattern of Aβ deposition and the effect of APOE (apolipoprotein E, APOE) ε4 on cognitive impairment in amnestic MCI (aMCI) and nonamnestic MCI (naMCI) patients has not been demonstrated. In this work, the amyloid-β (Aβ) load by [$^{18}$F]florbetapir PET imaging and cognitive performance is compared by comprehensive neuropsychological scales in partic

Additional indexing

Creators (Authors)

  • Wang, Mengjie
  • Zhang, Zhengwei
  • Wang, Ying
  • Huang, Lin
  • Huang, Qi
  • Ren, Shuhua
  • Qian, Luojun
  • Guo, Qihao
  • Guan, Yihui
  • Xie, Fang

Journal/Series Title

Journal/Series Title

Journal/Series Title

Volume

Volume

Volume
7

Number

Number

Number
8

Page range/Item number

Page range/Item number

Page range/Item number
2400008

Item Type

Item Type

Item Type
Journal Article

Dewey Decimal Classifikation

Dewey Decimal Classifikation

Dewey Decimal Classifikation

Keywords

amyloid beta-peptides, apolipoprotein E4, mild cognitive impairment, positron-emission tomography

Language

Language

Language
English

Publication date

Publication date

Publication date
2024-08

Date available

Date available

Date available
2024-07-16

Publisher

Publisher

Publisher

ISSN or e-ISSN

ISSN or e-ISSN

ISSN or e-ISSN
2366-3987

OA Status

OA Status

OA Status
Hybrid

Free Access at

Free Access at

Free Access at
DOI

Citations

Citation copied

Wang, M., Zhang, Z., Wang, Y., Huang, L., Huang, Q., Ren, S., Qian, L., Ni, R., Guo, Q., Guan, Y., & Xie, F. (2024). Effect of APOE ɛ4 Status on Brain Amyloid-β and Cognitive Function in Amnestic and Nonamnestic Mild Cognitive Impairment: A 18F Florbetapir PET-CT Study. Advanced Therapeutics, 7, 2400008. https://doi.org/10.1002/adtp.202400008

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