Left ventricular blood flow patterns at rest and under dobutamine stress in healthy pigs

Cesarovic, Nikola; Busch, Julia; Lipiski, Miriam; Fuetterer, Maximilian; Fleischmann, Thea; Born, Silvia; von Deuster, Constantin; Sauer, Mareike; Maisano, Francesco; Kozerke, Sebastian; Stoeck, Christian T

doi:10.1002/nbm.4022

Citations

Citation copied

Cesarovic, N., Busch, J., Lipiski, M., Fuetterer, M., Fleischmann, T., Born, S., von Deuster, C., Sauer, M., Maisano, F., Kozerke, S., & Stoeck, C. T. (2019). Left ventricular blood flow patterns at rest and under dobutamine stress in healthy pigs. NMR in Biomedicine, 32(1), e4022. https://doi.org/10.1002/nbm.4022

Abstract

Intracardiac blood flow patterns are affected by the morphology of cardiac structures and are set up to support the heart's pump function. Exercise affects contractility and chamber size as well as pre- and afterload. The aim of this study was to test the feasibility of four-dimensional phase contrast cardiovascular MRI under pharmacological stress and to study left ventricular blood flow under stress. 4D flow data were successfully acquired and analysed in 12 animals. During dobutamine infusion, heart rate and ejection fraction incre