Publication: Intracavitary cisplatin-fibrin followed by irradiation improved tumor control compared to the single treatments in a mesothelioma rat model
Intracavitary cisplatin-fibrin followed by irradiation improved tumor control compared to the single treatments in a mesothelioma rat model
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Kirschner, M. B., Meerang, M., Orlowski, V., Furrer, K., Tschanz, F., Grgic, I., Cecconi, V., van den Broek, M., Guckenberger, M., Pruschy, M., Lauk, O., & Opitz, I. (2024). Intracavitary cisplatin-fibrin followed by irradiation improved tumor control compared to the single treatments in a mesothelioma rat model. JTCVS Open, 22, 491–503. https://doi.org/10.1016/j.xjon.2024.07.024
Abstract
Abstract
Abstract
OBJECTIVE To test the safety and efficacy of combination treatment for pleural mesothelioma (PM) with intracavitary cisplatin-fibrin (cis-fib) plus hemithoracic irradiation (IR) applied after lung-sparing surgery in an orthotopic immunocompetent rat model.
METHODS We randomized male F344 rats into 5 groups: cis-fib (n = 9), 10 Gy IR (n = 6), 20 Gy IR (n = 9), cis-fib+10 Gy IR (n = 6), and cis-fib+20 Gy IR (n = 9). Subpleural tumor implantation was performed on day 0 with 1 million syngeneic rat mesothelioma cells (IL45-luciferase). T
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- Meerang, Mayura
- Orlowski, Vanessa
- Furrer, Katarzyna
- Tschanz, Fabienne
- Grgic, Ivo
- Cecconi, Virginia
- Guckenberger, Matthias
- Pruschy, Martin
- Lauk, Olivia
- Opitz, Isabelle
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Kirschner, M. B., Meerang, M., Orlowski, V., Furrer, K., Tschanz, F., Grgic, I., Cecconi, V., van den Broek, M., Guckenberger, M., Pruschy, M., Lauk, O., & Opitz, I. (2024). Intracavitary cisplatin-fibrin followed by irradiation improved tumor control compared to the single treatments in a mesothelioma rat model. JTCVS Open, 22, 491–503. https://doi.org/10.1016/j.xjon.2024.07.024
