Publication: Redox-directed cancer therapeutics: Taurolidine and Piperlongumine as broadly effective antineoplastic agents (review)
Redox-directed cancer therapeutics: Taurolidine and Piperlongumine as broadly effective antineoplastic agents (review)
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Möhler, H., Pfirrmann, R. W., & Frei, K. (2014). Redox-directed cancer therapeutics: Taurolidine and Piperlongumine as broadly effective antineoplastic agents (review). International Journal of Oncology, 45(4), 1329–1336. https://doi.org/10.3892/ijo.2014.2566
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Targeting the oxygen stress response pathway is considered a promising strategy to exert antineoplastic activity in a broad spectrum of tumor types. Supporting this view, we summarize the mechanism of action of Taurolidine and Piperlongumine, two antineoplastic agents with strikingly broad tumor selectivity. Taurolidine enhances the oxidative stress (ROS) selectively in tumor cells. Its cytotoxicity for various tumor cells in vitro and in vivo, which includes tumor stem cells, is based on the induction of programmed cell death, largel
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- Möhler, H
- Pfirrmann, R W
- Frei, K
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Möhler, H., Pfirrmann, R. W., & Frei, K. (2014). Redox-directed cancer therapeutics: Taurolidine and Piperlongumine as broadly effective antineoplastic agents (review). International Journal of Oncology, 45(4), 1329–1336. https://doi.org/10.3892/ijo.2014.2566