Publication: Inhibition of the c-Jun N-terminal kinase signaling pathway influences neurite outgrowth of spiral ganglion neurons in vitro
Inhibition of the c-Jun N-terminal kinase signaling pathway influences neurite outgrowth of spiral ganglion neurons in vitro
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Bodmer, D., Gloddek, B., Ryan, A. F., Huverstuhl, J., & Brors, D. (2002). Inhibition of the c-Jun N-terminal kinase signaling pathway influences neurite outgrowth of spiral ganglion neurons in vitro. The Laryngoscope, 112(11), 2057–2061. https://doi.org/10.1097/00005537-200211000-00028
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OBJECTIVES: Inhibitors of the c-Jun N-terminal kinase (JNK) signaling pathway have been demonstrated to protect hair cells of the auditory system and different types of neurons from various insults, and their use for future therapeutic applications has been proposed. In the study, we evaluated the effects of inhibition of the JNK pathway on process outgrowth from spiral ganglion neurons. METHODS: Spiral ganglion explants from rats (postnatal days 3-5) that were cultured on laminin were treated with neurotrophin-3 and/or the JNK signal
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- Bodmer, D
- Gloddek, B
- Ryan, A F
- Huverstuhl, J
- Brors, D
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Bodmer, D., Gloddek, B., Ryan, A. F., Huverstuhl, J., & Brors, D. (2002). Inhibition of the c-Jun N-terminal kinase signaling pathway influences neurite outgrowth of spiral ganglion neurons in vitro. The Laryngoscope, 112(11), 2057–2061. https://doi.org/10.1097/00005537-200211000-00028
