Publication: The vascular gene Apold1 is dispensable for normal development but controls angiogenesis under pathological conditions
The vascular gene Apold1 is dispensable for normal development but controls angiogenesis under pathological conditions
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Fan, Z., Ardicoglu, R., Batavia, A. A., Rust, R., von Ziegler, L., Waag, R., Zhang, J., Desgeorges, T., Sturman, O., Dang, H., Weber, R., Roszkowski, M., Moor, A. E., Schwab, M. E., Germain, P.-L., Bohacek, J., & De Bock, K. (2023). The vascular gene Apold1 is dispensable for normal development but controls angiogenesis under pathological conditions. Angiogenesis, 26, 385–407. https://doi.org/10.1007/s10456-023-09870-z
Abstract
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The molecular mechanisms of angiogenesis have been intensely studied, but many genes that control endothelial behavior and fate still need to be described. Here, we characterize the role of Apold1 (Apolipoprotein L domain containing 1) in angiogenesis in vivo and in vitro. Single-cell analyses reveal that - across tissues - the expression of Apold1 is restricted to the vasculature and that Apold1 expression in endothelial cells (ECs) is highly sensitive to environmental factors. Using Apold1$^{-/-}$
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Creators (Authors)
- Fan, Zheng
- Ardicoglu, Raphaela
- Batavia, Aashil A
- Rust, Ruslan
- von Ziegler, Lukas
- Waag, Rebecca
- Zhang, Jing
- Desgeorges, Thibaut
- Sturman, Oliver
- Dang, Hairuo
- Weber, Rebecca
- Roszkowski, Martin
- Moor, Andreas E
- Schwab, Martin E
- Germain, Pierre-Luc
- Bohacek, Johannes
- De Bock, Katrien
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Fan, Z., Ardicoglu, R., Batavia, A. A., Rust, R., von Ziegler, L., Waag, R., Zhang, J., Desgeorges, T., Sturman, O., Dang, H., Weber, R., Roszkowski, M., Moor, A. E., Schwab, M. E., Germain, P.-L., Bohacek, J., & De Bock, K. (2023). The vascular gene Apold1 is dispensable for normal development but controls angiogenesis under pathological conditions. Angiogenesis, 26, 385–407. https://doi.org/10.1007/s10456-023-09870-z
